Academy Awards
- Winner: 2004 - Best Performance by an Actress in a Leading Role - Million Dollar Baby
- Winner: 1999 - Best Performance by an Actress in a Leading Role - Boys Don’t Cry
Screen Actors Guild Awards
- Winner: 2004 - Outstanding Performance by a Female Actor in a Leading Role - Million Dollar Baby
- Nominee: 2005 - Outstanding Performance by a Cast in a Motion Picture - Million Dollar Baby
- Nominee: 2005 - Outstanding Performance by a Female Actor in a Television Movie or Miniseries - Iron Jawed Angels
- Nominee: 2000 - Outstanding Performance by a Female Actor in a Leading Role - Boys Don’t Cry
Golden Globe Awards
- Winner: 2005 - Best Performance by an Actress in a Motion Picture: Drama - Million Dollar Baby
- Nominee: 2005 - Best Performance by an Actress in a Mini-Series or Made for TV Movie - Iron Jawed Angels
- Winner: 2000 - Best Performance by an Actress in a Motion Picture: Drama - Boys Don’t Cry
Independent Spirit Awards
- Winner: 2000 - Best Female Lead - Boys Don’t Cry
MTV Movie Awards
- 2005: Nominee: MTV Movie Award - Best Female Performance - Million Dollar Baby
- 2000: Nominee: MTV Movie Award - Best Kiss - Boys Don’t Cry
- 2000: Nominee: MTV Movie Award - Best Female Performance - Boys Don’t Cry
BAFTA Awards
- Nominee: 2001 - Best Performance by an Actress in a Leading Role - Boys Don’t Cry
